Research
Introduction
At Plantocol, we believe that science and nature can work hand in hand to provide relief for those living with autoimmune conditions. Our patent-pending protocol is built on rigorous research, carefully selected ingredients, and a strategy that focuses on immune system modulation, inflammation management, and overall immune health. By leveraging scientific studies and pre-clinical results, we are dedicated to validating the effectiveness of our approach and providing a foundation for continued research in the field of autoimmunity.
Our protocol is not just a collection of supplements—it is a carefully formulated synergistic approach to immune health. Autoimmune diseases like Lupus SLE involve multiple physiological imbalances, including inflammation, oxidative stress, and immune dysregulation. The Plantocol protocol is designed to address these challenges holistically by combining:
Vitamin D3 + K2 for immune modulation and bone health
Magnesium Complex for cellular function and inflammation control
Resveratrol for antioxidant and anti-inflammatory support
Solanum Dulcamara for immune modulation and historical relevance in autoimmune relief
Each component was chosen based on scientific evidence supporting its role in immune system function and its potential benefits for autoimmune conditions.
Protocol Overview
Vitamin D3+K2
Background & History
Vitamin D3 is well known for its role in calcium metabolism and immune system regulation, while Vitamin K2 ensures proper calcium utilization. Research has shown that Vitamin D deficiency is commonly observed in autoimmune conditions, suggesting its crucial role in immune balance.
Relevance to Autoimmunity
Vitamin D3 supports immune homeostasis by promoting regulatory T cells and reducing the production of inflammatory cytokines such as IL-6 and TNF-alpha, both of which are associated with autoimmune flare-ups. Vitamin K2 plays an essential role in maintaining vascular and bone health, which can be compromised in conditions like Lupus and Rheumatoid Arthritis.
Supporting Research
A 2020 study published in Frontiers in Immunology highlighted the role of Vitamin D3 in reducing inflammatory markers in autoimmune diseases. (Source)
Research in The Journal of Rheumatology found that Vitamin K2 may have a protective effect against inflammation in autoimmune conditions. (Source)
A meta-analysis in Autoimmune Reviews suggests that Vitamin D supplementation can significantly improve disease outcomes in autoimmune patients. (Source)
Magnesium Complex
Background & History
Magnesium is essential for hundreds of enzymatic processes in the body, many of which play a role in inflammation control and immune function. The Plantocol protocol includes a unique Magnesium Complex combining several forms of magnesium to maximize absorption and benefits:
Magnesium Citrate – Known for its bioavailability and benefits for muscle relaxation and nerve function.
Magnesium Oxide – Supports cellular energy production and metabolic processes.
Magnesium Taurate – Plays a role in cardiovascular and nerve health.
Magnesium Bisglycinate Chelate – Highly absorbable and gentle on the stomach, supports stress response and muscle recovery.
Magnesium Aspartate – Aids in ATP production, essential for cellular energy.
Relevance to Autoimmunity
Magnesium has been shown to modulate immune responses by suppressing pro-inflammatory cytokines and reducing oxidative stress. Low magnesium levels are associated with higher levels of C-reactive protein (CRP), a biomarker for chronic inflammation linked to autoimmune diseases.
Supporting Research
A 2018 study in Nutrients demonstrated that magnesium supplementation reduced inflammation in individuals with chronic diseases. (Source)
Research published in Autoimmunity Reviews found that magnesium plays a role in reducing oxidative stress, which is a known trigger for autoimmune flare-ups. (Source)
Resveratrol
Background & History
Trans-Resveratrol is a potent polyphenol found in grapes and Japanese Knotweed, known for its antioxidant and anti-inflammatory properties.
Relevance to Autoimmunity
Resveratrol has been shown to modulate immune function by inhibiting the NF-kB pathway, which is responsible for upregulating inflammatory responses in autoimmune conditions. It also promotes the activation of SIRT1, a protein that regulates cellular stress responses.
Supporting Research
A 2021 study in International Journal of Molecular Sciences found that resveratrol can modulate immune response and decrease autoimmune flare-ups. (Source)
Research in Autoimmune Diseases journal highlighted resveratrol’s potential in reducing oxidative stress markers in autoimmune patients. (Source)
Solanum Dulcamara
Background & History
Also known as bittersweet nightshade, Solanum Dulcamara has been historically used in European herbal medicine for inflammatory conditions, particularly those affecting joints and the immune system.
Relevance to Autoimmunity
Solanum Dulcamara contains steroidal alkaloids that have demonstrated immunomodulatory effects, potentially balancing overactive immune responses in autoimmune conditions such as Lupus and Multiple Sclerosis.
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